FOXJ1
Gene Information
- Official Symbol: FOXJ1
- Official Name: forkhead box J1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2302
- UniProt: Q92949
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009].
- UniProt Summary: Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'- KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). {ECO:0000250|UniProtKB:Q61660}.
Pfam Domains GO Terms
Pfam Domains
| Fork head |
GO Terms
| regulation of central B cell tolerance induction |
| positive regulation of central B cell tolerance induction |
| positive regulation of lung ciliated cell differentiation |
| regulation of central tolerance induction |
| glomerular parietal epithelial cell development |
| positive regulation of central tolerance induction |
| positive regulation of B cell tolerance induction |
| regulation of lung ciliated cell differentiation |
| central tolerance induction |
| negative regulation of germinal center formation |
| regulation of B cell tolerance induction |
| glomerular parietal epithelial cell differentiation |
| metanephric part of ureteric bud development |
| negative regulation of interleukin-6 biosynthetic process |
| negative regulation of humoral immune response mediated by circulating immunoglobulin |
| negative regulation of T cell differentiation in thymus |
| positive regulation of tolerance induction |
| regulation of germinal center formation |
| glomerular epithelial cell development |
| negative regulation of B cell mediated immunity |
| negative regulation of immunoglobulin mediated immune response |
| regulation of humoral immune response mediated by circulating immunoglobulin |
| negative regulation of humoral immune response |
| tolerance induction |
| regulation of tolerance induction |
| glomerular epithelial cell differentiation |
| establishment of apical/basal cell polarity |
| glomerular epithelium development |
| left/right pattern formation |
| establishment of monopolar cell polarity |
| establishment or maintenance of monopolar cell polarity |
| motile cilium assembly |
| regulation of interleukin-6 biosynthetic process |
| regulation of T cell differentiation in thymus |
| metanephros morphogenesis |
| epithelial cell differentiation involved in kidney development |
| negative regulation of B cell activation |
| lung epithelium development |
| negative regulation of cytokine biosynthetic process |
| negative regulation of lymphocyte mediated immunity |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| cell differentiation involved in kidney development |
| negative regulation of interleukin-6 production |
| negative regulation of T cell differentiation |
| negative regulation of adaptive immune response |
| establishment or maintenance of apical/basal cell polarity |
| establishment or maintenance of bipolar cell polarity |
| negative regulation of leukocyte mediated immunity |
| glomerulus development |
| regulation of immunoglobulin mediated immune response |
| regulation of B cell mediated immunity |
| negative regulation of lymphocyte differentiation |
| positive regulation of epithelial cell differentiation |
| negative regulation of T cell proliferation |
| negative regulation of lymphocyte proliferation |
| negative regulation of mononuclear cell proliferation |
| transcription regulatory region sequence-specific DNA binding |
| negative regulation of leukocyte proliferation |
| negative regulation of NF-kappaB transcription factor activity |
| metanephros development |
| kidney morphogenesis |
| ureteric bud development |
| mesonephric epithelium development |
| mesonephric tubule development |
| mesonephros development |
| nephron epithelium development |
| activation of GTPase activity |
| negative regulation of leukocyte differentiation |
| regulation of cytokine biosynthetic process |
| negative regulation of T cell activation |
| determination of left/right symmetry |
| establishment of cell polarity |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| determination of bilateral symmetry |
| specification of symmetry |
| nephron development |
| kidney epithelium development |
| negative regulation of hemopoiesis |
| regulation of humoral immune response |
| regulation of T cell differentiation |
| regulation of interleukin-6 production |
| regulation of epithelial cell differentiation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of lymphocyte activation |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| regulation of T cell proliferation |
| negative regulation of DNA-binding transcription factor activity |
| regulation of adaptive immune response |
| regulation of lymphocyte differentiation |
| lung development |
| respiratory tube development |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| epithelial cell development |
| respiratory system development |
| negative regulation of cell activation |
| establishment or maintenance of cell polarity |
| regulation of leukocyte mediated immunity |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of leukocyte proliferation |
| kidney development |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| renal system development |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| urogenital system development |
| regionalization |
| cilium assembly |
| humoral immune response |
| cilium organization |
| leukocyte migration |
| regulation of cell-cell adhesion |
| positive regulation of GTPase activity |
| regulation of DNA-binding transcription factor activity |
| pattern specification process |
| negative regulation of immune system process |
| plasma membrane bounded cell projection assembly |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of hemopoiesis |
| cell projection assembly |
| regulation of immune effector process |
| regulation of GTPase activity |
| actin cytoskeleton organization |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| regulation of lymphocyte activation |
| heart development |
| spermatogenesis |
| male gamete generation |
| actin filament-based process |
| regulation of leukocyte activation |
| regulation of cell activation |
| immune system development |
| negative regulation of cell population proliferation |
| DNA-binding transcription factor activity |
| regulation of cell adhesion |
| epithelial cell differentiation |
| gamete generation |
| regulation of cytokine production |
| negative regulation of cell differentiation |
| brain development |
| organelle assembly |
| positive regulation of hydrolase activity |
| head development |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| central nervous system development |
| multi-organism reproductive process |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| epithelium development |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of hydrolase activity |
| locomotion |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of cell differentiation |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| LLY-284 2.6μM R06 exp291 | -1.9 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12331
- Expression level (log2 read counts): -5.6
Expression Distribution
FOXJ1 Expression in NALM6 Cells: -5.6
