FRMD4A
Gene Information
- Official Symbol: FRMD4A
- Official Name: FERM domain containing 4A
- Aliases and Previous Symbols: N/A
- Entrez ID: 55691
- UniProt: Q9P2Q2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
- UniProt Summary: Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8664
- Expression level (log2 read counts): 3.43
FRMD4A Expression in NALM6 Cells: 3.43
