UniProt Summary: May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). {ECO:0000269|PubMed:19706687}.
Pfam DomainsGO Terms
Pfam Domains
FERM M
FERM N
PDZ
FERM C
GO Terms
1-phosphatidylinositol binding
bicellular tight junction assembly
tight junction assembly
tight junction organization
apical junction assembly
cell-cell junction assembly
bicellular tight junction
cell-cell junction organization
cell junction assembly
basolateral plasma membrane
cell junction organization
cytoskeleton
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739