FYB
Gene Information
- Official Symbol: FYB1
- Official Name: FYN binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2533
- UniProt: O15117
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
- UniProt Summary: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12286
- Expression level (log2 read counts): -3.9
FYB Expression in NALM6 Cells: -3.9
