GALP
Gene Information
- Official Symbol: GALP
- Official Name: galanin like peptide
- Aliases and Previous Symbols: N/A
- Entrez ID: 85569
- UniProt: Q9UBC7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014].
- UniProt Summary: Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4889
- Expression level (log2 read counts): -7.68
GALP Expression in NALM6 Cells: -7.68
