GINS4

Entrez Summary: N/A
UniProt Summary: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA. {ECO:0000269|PubMed:17417653}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 597/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	23/28
bone	23/26
breast	28/33
central nervous system	50/56
cervix	3/4
colorectal	16/17
esophagus	10/13
fibroblast	1/1
gastric	12/16
kidney	17/21
liver	18/20
lung	59/75
lymphocyte	11/16
ovary	21/26
pancreas	22/24
peripheral nervous system	16/16
plasma cell	9/15
prostate	1/1
skin	17/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	21/29
uterus	3/5

Expression Distribution