GIT2
Gene Information
- Official Symbol: GIT2
- Official Name: GIT ArfGAP 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 9815
- UniProt: Q14161
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008].
- UniProt Summary: GTPase-activating protein for the ADP ribosylation factor family.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11724
- Expression level (log2 read counts): 6.23
GIT2 Expression in NALM6 Cells: 6.23
