Pfam Domains GO Terms
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| signal transduction involved in mitotic DNA integrity checkpoint |
| signal transduction involved in mitotic DNA damage checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| mitotic G1/S transition checkpoint |
| mitotic G1 DNA damage checkpoint |
| G1 DNA damage checkpoint |
| extrinsic component of membrane |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in cell cycle checkpoint |
| DNA damage response, signal transduction by p53 class mediator |
| positive regulation of cell cycle arrest |
| mitotic DNA damage checkpoint |
| anchored component of membrane |
| negative regulation of G1/S transition of mitotic cell cycle |
| mitotic DNA integrity checkpoint |
| signal transduction in response to DNA damage |
| negative regulation of cell cycle G1/S phase transition |
| regulation of cell cycle arrest |
| signal transduction by p53 class mediator |
| DNA damage checkpoint |
| DNA integrity checkpoint |
| regulation of G1/S transition of mitotic cell cycle |
| mitotic cell cycle checkpoint |
| regulation of cell cycle G1/S phase transition |
| cell cycle checkpoint |
| negative regulation of mitotic cell cycle phase transition |
| negative regulation of cell cycle phase transition |
| positive regulation of cell cycle process |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| positive regulation of cell cycle |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| negative regulation of cell population proliferation |
| mitotic cell cycle |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| apoptotic process |
| cell cycle process |
| programmed cell death |
| cell death |
| regulation of cell cycle |
| cell cycle |
| regulation of cell population proliferation |
| intracellular signal transduction |
| cellular response to stress |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| 1-Methyl-nicotinamide-chloride 1000μM R03 exp113 | -1.71 |
| 6-Thio-2-deoxyguanosine 2μM R06 exp259 | 2.18 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution