GNAL
Gene Information
- Official Symbol: GNAL
- Official Name: G protein subunit alpha L
- Aliases and Previous Symbols: N/A
- Entrez ID: 2774
- UniProt: P38405
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
- UniProt Summary: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16719
- Expression level (log2 read counts): 2.75
GNAL Expression in NALM6 Cells: 2.75
