UniProt Summary: Orphan receptor. Signals via G(s)-alpha family of G- proteins (PubMed:22025619, PubMed:22575658). Has protumorigenic function especially in glioblastoma (PubMed:27775701). {ECO:0000269|PubMed:22025619, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:27775701}.
Pfam DomainsGO Terms
Pfam Domains
Dicty CAR
GPS
7tm 2
GO Terms
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
second-messenger-mediated signaling
G protein-coupled receptor activity
G protein-coupled receptor signaling pathway
integral component of plasma membrane
intracellular signal transduction
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739