GPR35
Gene Information
- Official Symbol: GPR35
- Official Name: G protein-coupled receptor 35
- Aliases and Previous Symbols: N/A
- Entrez ID: 2859
- UniProt: Q9HC97
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins. {ECO:0000269|PubMed:16754668}.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| negative regulation of neuronal action potential |
| regulation of neuronal action potential |
| negative regulation of transmission of nerve impulse |
| C-X-C chemokine receptor activity |
| negative regulation of action potential |
| negative regulation of voltage-gated calcium channel activity |
| regulation of transmission of nerve impulse |
| negative regulation of nervous system process |
| positive regulation of Rho protein signal transduction |
| positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
| regulation of voltage-gated calcium channel activity |
| negative regulation of calcium ion transmembrane transporter activity |
| negative regulation of calcium ion transmembrane transport |
| negative regulation of cation channel activity |
| regulation of action potential |
| negative regulation of calcium ion transport |
| positive regulation of Ras protein signal transduction |
| positive regulation of small GTPase mediated signal transduction |
| negative regulation of ion transmembrane transporter activity |
| negative regulation of transporter activity |
| chemokine-mediated signaling pathway |
| negative regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transporter activity |
| cellular response to chemokine |
| response to chemokine |
| negative regulation of ion transmembrane transport |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| negative regulation of transmembrane transport |
| regulation of nervous system process |
| regulation of Rho protein signal transduction |
| regulation of calcium ion transmembrane transport |
| negative regulation of ion transport |
| regulation of cation channel activity |
| regulation of Ras protein signal transduction |
| regulation of calcium ion transport |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of transporter activity |
| positive regulation of cytosolic calcium ion concentration |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| regulation of small GTPase mediated signal transduction |
| regulation of metal ion transport |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cytokine-mediated signaling pathway |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| cellular chemical homeostasis |
| ion homeostasis |
| cellular homeostasis |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| response to cytokine |
| cytoskeleton organization |
| chemical homeostasis |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| integral component of plasma membrane |
| homeostatic process |
| positive regulation of signal transduction |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7564
- Expression level (log2 read counts): 1.16
Expression Distribution
GPR35 Expression in NALM6 Cells: 1.16
