GPR4
Gene Information
- Official Symbol: GPR4
- Official Name: G protein-coupled receptor 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 2828
- UniProt: P46093
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. {ECO:0000269|PubMed:12955148, ECO:0000269|PubMed:17462861}.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| glomerular mesangial cell development |
| glomerular mesangial cell differentiation |
| mesangial cell development |
| mesangial cell differentiation |
| pericyte cell differentiation |
| glomerular mesangium development |
| angiogenesis involved in wound healing |
| glomerulus vasculature development |
| renal system vasculature development |
| kidney vasculature development |
| response to acidic pH |
| positive regulation of Rho protein signal transduction |
| epithelial cell differentiation involved in kidney development |
| positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
| response to pH |
| cell differentiation involved in kidney development |
| glomerulus development |
| positive regulation of Ras protein signal transduction |
| positive regulation of small GTPase mediated signal transduction |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| negative regulation of vasculature development |
| nephron development |
| regulation of Rho protein signal transduction |
| epithelial cell development |
| connective tissue development |
| regulation of Ras protein signal transduction |
| kidney development |
| positive regulation of cytosolic calcium ion concentration |
| renal system development |
| regulation of angiogenesis |
| angiogenesis |
| urogenital system development |
| regulation of vasculature development |
| regulation of cytosolic calcium ion concentration |
| regulation of small GTPase mediated signal transduction |
| blood vessel morphogenesis |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| wound healing |
| blood vessel development |
| divalent inorganic cation homeostasis |
| vasculature development |
| cardiovascular system development |
| cellular metal ion homeostasis |
| response to wounding |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| tube morphogenesis |
| epithelial cell differentiation |
| cation homeostasis |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| cellular chemical homeostasis |
| ion homeostasis |
| tube development |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| negative regulation of developmental process |
| positive regulation of intracellular signal transduction |
| regulation of anatomical structure morphogenesis |
| chemical homeostasis |
| epithelium development |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| G protein-coupled receptor signaling pathway |
| integral component of plasma membrane |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| tissue development |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10579
- Expression level (log2 read counts): 1.11
Expression Distribution
GPR4 Expression in NALM6 Cells: 1.11
