GPRC6A
Gene Information
- Official Symbol: GPRC6A
- Official Name: G protein-coupled receptor class C group 6 member A
- Aliases and Previous Symbols: N/A
- Entrez ID: 222545
- UniProt: Q5T6X5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids. {ECO:0000269|PubMed:15576628, ECO:0000269|PubMed:20947496}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16400
- Expression level (log2 read counts): -7.68
GPRC6A Expression in NALM6 Cells: -7.68
