GTF2F1
Gene Information
- Official Symbol: GTF2F1
- Official Name: general transcription factor IIF subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2962
- UniProt: P35269
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.
Pfam Domains GO Terms
Pfam Domains
| TFIIF alpha |
GO Terms
| transcription factor TFIIF complex |
| phosphatase activator activity |
| RNA polymerase II general transcription initiation factor activity |
| positive regulation of transcription elongation from RNA polymerase II promoter |
| regulation of transcription elongation from RNA polymerase II promoter |
| positive regulation of DNA-templated transcription, elongation |
| 7-methylguanosine mRNA capping |
| RNA capping |
| 7-methylguanosine RNA capping |
| transcription factor TFIID complex |
| positive regulation of viral transcription |
| promoter-specific chromatin binding |
| regulation of DNA-templated transcription, elongation |
| regulation of viral transcription |
| snRNA transcription by RNA polymerase II |
| snRNA transcription |
| transcription elongation from RNA polymerase II promoter |
| fibroblast growth factor receptor signaling pathway |
| protein phosphatase binding |
| DNA-templated transcription, elongation |
| ncRNA transcription |
| negative regulation of protein binding |
| positive regulation of viral process |
| cellular response to fibroblast growth factor stimulus |
| response to fibroblast growth factor |
| negative regulation of binding |
| transcription initiation from RNA polymerase II promoter |
| regulation of viral process |
| DNA-templated transcription, initiation |
| regulation of protein binding |
| regulation of symbiosis, encompassing mutualism through parasitism |
| protein domain specific binding |
| response to virus |
| transcription coactivator activity |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| transcription factor binding |
| regulation of binding |
| RNA splicing |
| mRNA processing |
| transcription by RNA polymerase II |
| cellular response to growth factor stimulus |
| positive regulation of multi-organism process |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| response to growth factor |
| cell junction |
| protein-containing complex |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| intracellular membrane-bounded organelle |
| mRNA metabolic process |
| enzyme linked receptor protein signaling pathway |
| regulation of multi-organism process |
| RNA processing |
| nucleobase-containing compound biosynthetic process |
| negative regulation of molecular function |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| response to biotic stimulus |
| RNA binding |
| positive regulation of catalytic activity |
| DNA binding |
| response to endogenous stimulus |
| positive regulation of transcription, DNA-templated |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Etoposide 10μM R00 exp20 | -1.76 |
| Amiloride 100μM R08 exp447 | -1.71 |
| Cadmium 60μM R08 exp462 | 1.95 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1961
- Expression level (log2 read counts): 6.52
Expression Distribution
GTF2F1 Expression in NALM6 Cells: 6.52
