Entrez Summary: There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008].
UniProt Summary: Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
Pfam DomainsGO Terms
Pfam Domains
G6PD N
Glucosamine iso
G6PD C
GO Terms
glucose 1-dehydrogenase [NAD(P)] activity
glucose-6-phosphate dehydrogenase activity
6-phosphogluconolactonase activity
pentose-phosphate shunt
NADPH regeneration
glucose 6-phosphate metabolic process
NADP metabolic process
NADP binding
glucose metabolic process
hexose metabolic process
monosaccharide metabolic process
endoplasmic reticulum lumen
generation of precursor metabolites and energy
carbohydrate metabolic process
organophosphate metabolic process
oxidation-reduction process
carbohydrate derivative metabolic process
small molecule metabolic process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)