HADHA

• Official Symbol: HADHA
• Official Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
• Aliases and Previous Symbols: N/A
• Entrez ID: 3030
• UniProt: P40939
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008].
• UniProt Summary: Bifunctional subunit.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 3618
• Expression level (log2 read counts): 7.33

Expression Distribution

×

HADHA Expression in NALM6 Cells: 7.33