HDDC3
Gene Information
- Official Symbol: HDDC3
- Official Name: HD domain containing 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 374659
- UniProt: Q8N4P3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: ppGpp hydrolyzing enzyme involved in starvation response. {ECO:0000269|PubMed:20818390}.
Pfam Domains GO Terms
Pfam Domains
| HD |
GO Terms
| guanosine tetraphosphate catabolic process |
| purine ribonucleoside bisphosphate catabolic process |
| guanosine tetraphosphate metabolic process |
| guanosine-3,5-bis(diphosphate) 3-diphosphatase activity |
| guanosine-containing compound catabolic process |
| nucleoside bisphosphate catabolic process |
| ribonucleoside bisphosphate catabolic process |
| purine nucleoside bisphosphate catabolic process |
| purine ribonucleoside catabolic process |
| purine nucleoside catabolic process |
| ribonucleoside catabolic process |
| purine ribonucleoside bisphosphate metabolic process |
| purine ribonucleotide catabolic process |
| ribonucleotide catabolic process |
| nucleoside catabolic process |
| guanosine-containing compound metabolic process |
| purine nucleotide catabolic process |
| glycosyl compound catabolic process |
| nucleobase-containing small molecule catabolic process |
| purine-containing compound catabolic process |
| purine ribonucleoside metabolic process |
| purine nucleoside metabolic process |
| nucleotide catabolic process |
| nucleoside phosphate catabolic process |
| ribonucleoside metabolic process |
| nucleobase-containing small molecule biosynthetic process |
| nucleoside metabolic process |
| organophosphate catabolic process |
| ribonucleoside bisphosphate metabolic process |
| nucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| glycosyl compound metabolic process |
| carbohydrate derivative catabolic process |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| purine-containing compound metabolic process |
| nucleobase-containing compound catabolic process |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| small molecule catabolic process |
| aromatic compound catabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic cyclic compound catabolic process |
| nucleobase-containing small molecule metabolic process |
| small molecule biosynthetic process |
| organophosphate metabolic process |
| carbohydrate derivative metabolic process |
| organonitrogen compound catabolic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.514 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4687
- Expression level (log2 read counts): 3.5
Expression Distribution
HDDC3 Expression in NALM6 Cells: 3.5
