HEBP2
Gene Information
- Official Symbol: HEBP2
- Official Name: heme binding protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 23593
- UniProt: Q9Y5Z4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016].
- UniProt Summary: Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. {ECO:0000269|PubMed:17098234}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18991
- Expression level (log2 read counts): 2.61
HEBP2 Expression in NALM6 Cells: 2.61
