HECTD3
Gene Information
- Official Symbol: HECTD3
- Official Name: HECT domain E3 ubiquitin protein ligase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 79654
- UniProt: Q5T447
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012].
- UniProt Summary: E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). {ECO:0000250|UniProtKB:Q3U487, ECO:0000269|PubMed:18194665}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9739
- Expression level (log2 read counts): 5.36
HECTD3 Expression in NALM6 Cells: 5.36
