Pfam Domains GO Terms
| Hairy orange |
| HLH |
| GABAergic neuron differentiation in basal ganglia |
| suckling behavior |
| GABAergic neuron differentiation |
| multicellular organism aging |
| multi-organism behavior |
| multicellular organism growth |
| feeding behavior |
| post-embryonic development |
| transcription factor complex |
| anterior/posterior pattern specification |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| aging |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regionalization |
| developmental growth |
| growth |
| pattern specification process |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| behavior |
| regulation of neurogenesis |
| negative regulation of transcription by RNA polymerase II |
| protein homodimerization activity |
| regulation of nervous system development |
| regulation of cell development |
| central nervous system development |
| neuron differentiation |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| S-DABN 8μM R03 exp112 | -1.86 |
| Nicotinamide 2000μM R01 exp50 | -1.81 |
| Milciclib 2μM R08 exp502 | 1.75 |
| Lead acetate 990μM R08 exp496 | 2.18 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution