HIBCH
Gene Information
- Official Symbol: HIBCH
- Official Name: 3-hydroxyisobutyryl-CoA hydrolase
- Aliases and Previous Symbols: N/A
- Entrez ID: 26275
- UniProt: Q6NVY1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the enzyme responsible for hydrolysis of both HIBYL-CoA and beta-hydroxypropionyl-CoA. Mutations in this gene have been associated with 3-hyroxyisobutyryl-CoA hydrolase deficiency. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
- UniProt Summary: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000269|PubMed:8824301}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13314
- Expression level (log2 read counts): 4.89
HIBCH Expression in NALM6 Cells: 4.89
