HIST2H3D

Entrez Summary: N/A
UniProt Summary: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 193/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	10/28
blood	4/28
bone	8/26
breast	5/33
central nervous system	14/56
cervix	4/4
colorectal	3/17
esophagus	3/13
fibroblast	1/1
gastric	7/16
kidney	6/21
liver	3/20
lung	16/75
lymphocyte	1/16
ovary	4/26
pancreas	6/24
peripheral nervous system	6/16
plasma cell	4/15
prostate	0/1
skin	5/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	10/29
uterus	0/5

Expression Distribution