HLA-G
Gene Information
- Official Symbol: HLA-G
- Official Name: major histocompatibility complex, class I, G
- Aliases and Previous Symbols: N/A
- Entrez ID: 3135
- UniProt: P17693
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008].
- UniProt Summary: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.
Pfam Domains GO Terms
Pfam Domains
| MHC I |
| C1-set |
GO Terms
| B cell tolerance induction |
| peripheral B cell tolerance induction |
| tolerance induction dependent upon immune response |
| peripheral tolerance induction |
| CD8 receptor binding |
| protection from natural killer cell mediated cytotoxicity |
| cis-Golgi network membrane |
| negative regulation of dendritic cell differentiation |
| immune response-inhibiting cell surface receptor signaling pathway |
| positive regulation of T cell tolerance induction |
| positive regulation of natural killer cell cytokine production |
| negative regulation of T cell mediated cytotoxicity |
| antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway |
| antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent |
| immune response-inhibiting signal transduction |
| regulation of natural killer cell cytokine production |
| antigen processing and presentation of endogenous peptide antigen via MHC class Ib |
| positive regulation of tolerance induction |
| regulation of T cell tolerance induction |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent |
| positive regulation of macrophage cytokine production |
| antigen processing and presentation of peptide antigen via MHC class Ib |
| MHC class I protein complex |
| positive regulation of cellular senescence |
| regulation of dendritic cell differentiation |
| tolerance induction |
| antigen processing and presentation of endogenous peptide antigen |
| positive regulation of regulatory T cell differentiation |
| antigen processing and presentation of endogenous peptide antigen via MHC class I |
| negative regulation of natural killer cell mediated cytotoxicity |
| regulation of macrophage cytokine production |
| positive regulation of cell aging |
| negative regulation of natural killer cell mediated immunity |
| antigen processing and presentation via MHC class Ib |
| regulation of tolerance induction |
| negative regulation of leukocyte mediated cytotoxicity |
| filopodium membrane |
| positive regulation of myeloid leukocyte cytokine production involved in immune response |
| positive regulation of endothelial cell apoptotic process |
| negative regulation of T cell mediated immunity |
| antigen processing and presentation of endogenous antigen |
| negative regulation of cell killing |
| positive regulation of T cell mediated cytotoxicity |
| integral component of lumenal side of endoplasmic reticulum membrane |
| regulation of regulatory T cell differentiation |
| positive regulation of epithelial cell apoptotic process |
| protein homotrimerization |
| positive regulation of natural killer cell mediated immunity |
| regulation of T cell mediated cytotoxicity |
| peptide antigen binding |
| positive regulation of interleukin-12 production |
| negative regulation of lymphocyte mediated immunity |
| negative regulation of G0 to G1 transition |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of cellular senescence |
| regulation of natural killer cell mediated cytotoxicity |
| regulation of G0 to G1 transition |
| regulation of natural killer cell mediated immunity |
| negative regulation of adaptive immune response |
| negative regulation of protein kinase B signaling |
| positive regulation of T cell mediated immunity |
| regulation of cell aging |
| negative regulation of leukocyte mediated immunity |
| regulation of endothelial cell apoptotic process |
| cellular defense response |
| ER to Golgi transport vesicle membrane |
| positive regulation of cytokine production involved in immune response |
| regulation of interleukin-12 production |
| protein trimerization |
| positive regulation of leukocyte mediated cytotoxicity |
| negative regulation of innate immune response |
| negative regulation of T cell proliferation |
| type I interferon signaling pathway |
| cellular response to type I interferon |
| positive regulation of cell killing |
| regulation of T cell mediated immunity |
| response to type I interferon |
| interferon-gamma-mediated signaling pathway |
| phagocytic vesicle membrane |
| negative regulation of lymphocyte proliferation |
| negative regulation of mononuclear cell proliferation |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| regulation of leukocyte mediated cytotoxicity |
| regulation of epithelial cell apoptotic process |
| negative regulation of leukocyte proliferation |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| positive regulation of T cell differentiation |
| recycling endosome membrane |
| regulation of cytokine production involved in immune response |
| negative regulation of response to biotic stimulus |
| positive regulation of lymphocyte differentiation |
| positive regulation of production of molecular mediator of immune response |
| antigen processing and presentation of peptide antigen via MHC class I |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of leukocyte differentiation |
| regulation of cell killing |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| negative regulation of T cell activation |
| negative regulation of vasculature development |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| positive regulation of leukocyte mediated immunity |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| regulation of production of molecular mediator of immune response |
| negative regulation of lymphocyte activation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of leukocyte differentiation |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| early endosome membrane |
| regulation of T cell proliferation |
| regulation of adaptive immune response |
| cellular response to interferon-gamma |
| regulation of lymphocyte differentiation |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| antigen processing and presentation of exogenous peptide antigen |
| response to interferon-gamma |
| antigen processing and presentation of exogenous antigen |
| positive regulation of hemopoiesis |
| antigen processing and presentation of peptide antigen |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| negative regulation of defense response |
| regulation of lymphocyte proliferation |
| B cell mediated immunity |
| regulation of mononuclear cell proliferation |
| negative regulation of multi-organism process |
| positive regulation of leukocyte cell-cell adhesion |
| antigen processing and presentation |
| positive regulation of immune effector process |
| regulation of protein kinase B signaling |
| regulation of leukocyte proliferation |
| positive regulation of cell-cell adhesion |
| early endosome |
| lymphocyte mediated immunity |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of angiogenesis |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| regulation of vasculature development |
| negative regulation of cell cycle process |
| signaling receptor binding |
| protein homooligomerization |
| positive regulation of innate immune response |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| negative regulation of response to external stimulus |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| negative regulation of intracellular signal transduction |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| protein complex oligomerization |
| regulation of response to biotic stimulus |
| negative regulation of cell cycle |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| adaptive immune response |
| Golgi membrane |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of cytokine production |
| positive regulation of cell death |
| negative regulation of cell differentiation |
| regulation of cellular response to stress |
| regulation of cell cycle process |
| regulation of defense response |
| leukocyte mediated immunity |
| innate immune response |
| regulation of multi-organism process |
| positive regulation of immune response |
| protein homodimerization activity |
| negative regulation of developmental process |
| defense response to other organism |
| positive regulation of cell differentiation |
| cellular response to cytokine stimulus |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| positive regulation of immune system process |
| regulation of immune response |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| regulation of response to stress |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| extracellular space |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
| immune response |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Citral 50μM R06 exp274 | 1.76 |
| Bisphenol A 100μM R06 exp269 | 1.82 |
| Centrinone 0.5μM R07 exp343 | 2.1 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12484
- Expression level (log2 read counts): 1.87
Expression Distribution
HLA-G Expression in NALM6 Cells: 1.87
