HMCN1
Gene Information
- Official Symbol: HMCN1
- Official Name: hemicentin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 83872
- UniProt: Q96RW7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration. [provided by RefSeq, Jul 2008].
- UniProt Summary: Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration. {ECO:0000250|UniProtKB:D3YXG0}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16223
- Expression level (log2 read counts): -7.68
HMCN1 Expression in NALM6 Cells: -7.68
