Entrez Summary: This gene encodes a serpin-domain containing protein that may function as a serine protease inhibitor. This gene is primarily expressed in cells of myeloid lineage. A polymorphism in this gene may result in the expression a splice variant that encodes a minor histocompatibility antigen. [provided by RefSeq, Oct 2010].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
Serpin
GO Terms
serine-type endopeptidase inhibitor activity
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
activation of immune response
regulation of proteolysis
negative regulation of catalytic activity
positive regulation of immune response
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
positive regulation of immune system process
regulation of immune response
regulation of hydrolase activity
extracellular space
regulation of immune system process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)