HMX1
Gene Information
- Official Symbol: HMX1
- Official Name: H6 family homeobox 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3166
- UniProt: Q9NP08
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a transcription factor that belongs to the H6 family of homeobox proteins. This protein can bind a 5'-CAAG-3' core DNA sequence, and it is involved in the development of craniofacial structures. Mutations in this gene cause oculoauricular syndrome, a disorder of the eye and external ear. [provided by RefSeq, Oct 2009].
- UniProt Summary: DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear. {ECO:0000269|PubMed:10206974}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7348
- Expression level (log2 read counts): -6.6
HMX1 Expression in NALM6 Cells: -6.6
