HRC
Gene Information
- Official Symbol: HRC
- Official Name: histidine rich calcium binding protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 3270
- UniProt: P23327
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of relaxation of cardiac muscle |
| positive regulation of relaxation of muscle |
| regulation of relaxation of cardiac muscle |
| sarcoplasmic reticulum lumen |
| regulation of cell communication by electrical coupling involved in cardiac conduction |
| regulation of relaxation of muscle |
| regulation of cell communication by electrical coupling |
| regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| positive regulation of heart rate |
| regulation of cardiac muscle contraction by calcium ion signaling |
| regulation of ryanodine-sensitive calcium-release channel activity |
| regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| positive regulation of heart contraction |
| regulation of cardiac conduction |
| positive regulation of blood circulation |
| regulation of cardiac muscle contraction |
| regulation of release of sequestered calcium ion into cytosol |
| ATPase binding |
| regulation of calcium ion transmembrane transporter activity |
| regulation of striated muscle contraction |
| regulation of heart rate |
| regulation of calcium-mediated signaling |
| regulation of calcium ion transport into cytosol |
| regulation of sequestering of calcium ion |
| ion channel binding |
| Z disc |
| regulation of peptidyl-serine phosphorylation |
| calcium-mediated signaling |
| regulation of calcium ion transmembrane transport |
| regulation of muscle contraction |
| regulation of cation channel activity |
| regulation of muscle system process |
| regulation of heart contraction |
| regulation of calcium ion transport |
| muscle contraction |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of transporter activity |
| regulation of blood circulation |
| muscle system process |
| endoplasmic reticulum lumen |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| post-translational protein modification |
| regulation of metal ion transport |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| divalent inorganic cation homeostasis |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| cellular chemical homeostasis |
| ion homeostasis |
| cellular homeostasis |
| regulation of cellular localization |
| chemical homeostasis |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| homeostatic process |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rucaparib 6.5μM R08 exp520 | -1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15507
- Expression level (log2 read counts): -1.69
Expression Distribution
HRC Expression in NALM6 Cells: -1.69
