HSPB6
Gene Information
- Official Symbol: HSPB6
- Official Name: heat shock protein family B (small) member 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 126393
- UniProt: O14558
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012].
- UniProt Summary: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. {ECO:0000269|PubMed:14717697, ECO:0000269|PubMed:19845507, ECO:0000269|PubMed:20843828, ECO:0000269|PubMed:22427880, ECO:0000305, ECO:0000305|PubMed:22794279}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13798
- Expression level (log2 read counts): -3.7
HSPB6 Expression in NALM6 Cells: -3.7
