HYOU1
Gene Information
- Official Symbol: HYOU1
- Official Name: hypoxia up-regulated 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 10525
- UniProt: Q9Y4L1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. {ECO:0000269|PubMed:10037731}.
Pfam Domains GO Terms
Pfam Domains
| HSP70 |
GO Terms
| negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway |
| regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway |
| regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
| negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
| negative regulation of cellular response to hypoxia |
| endoplasmic reticulum chaperone complex |
| regulation of cellular response to hypoxia |
| endocytic vesicle lumen |
| negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| smooth endoplasmic reticulum |
| regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| negative regulation of response to endoplasmic reticulum stress |
| response to ischemia |
| IRE1-mediated unfolded protein response |
| regulation of response to endoplasmic reticulum stress |
| negative regulation of intrinsic apoptotic signaling pathway |
| chaperone binding |
| endoplasmic reticulum unfolded protein response |
| cellular response to unfolded protein |
| negative regulation of neuron apoptotic process |
| cellular response to topologically incorrect protein |
| regulation of intrinsic apoptotic signaling pathway |
| response to unfolded protein |
| response to topologically incorrect protein |
| cellular response to hypoxia |
| cellular response to decreased oxygen levels |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| cellular response to oxygen levels |
| negative regulation of apoptotic signaling pathway |
| receptor-mediated endocytosis |
| response to endoplasmic reticulum stress |
| endoplasmic reticulum lumen |
| regulation of neuron death |
| response to hypoxia |
| response to decreased oxygen levels |
| Golgi vesicle transport |
| response to oxygen levels |
| regulation of apoptotic signaling pathway |
| focal adhesion |
| negative regulation of intracellular signal transduction |
| endocytosis |
| import into cell |
| regulation of cellular response to stress |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| negative regulation of cell death |
| endoplasmic reticulum |
| response to abiotic stimulus |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of response to stress |
| ATP binding |
| intracellular transport |
| regulation of apoptotic process |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| regulation of cell death |
| cellular response to stress |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| extracellular region |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 698/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 27/28 |
| blood | 25/28 |
| bone | 26/26 |
| breast | 26/33 |
| central nervous system | 55/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 14/16 |
| kidney | 20/21 |
| liver | 19/20 |
| lung | 69/75 |
| lymphocyte | 15/16 |
| ovary | 24/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 27/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 253
- Expression level (log2 read counts): 9.17
Expression Distribution
HYOU1 Expression in NALM6 Cells: 9.17
