IFI6
Gene Information
- Official Symbol: IFI6
- Official Name: interferon alpha inducible protein 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 2537
- UniProt: P09912
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ifi-6-16 |
GO Terms
| negative regulation of mitochondrial depolarization |
| negative regulation of membrane depolarization |
| regulation of mitochondrial depolarization |
| release of cytochrome c from mitochondria |
| cellular response to virus |
| negative regulation of signal transduction in absence of ligand |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| regulation of membrane depolarization |
| regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| apoptotic mitochondrial changes |
| type I interferon signaling pathway |
| cellular response to type I interferon |
| regulation of mitochondrial membrane potential |
| response to type I interferon |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of epidermal growth factor receptor signaling pathway |
| negative regulation of cysteine-type endopeptidase activity |
| regulation of ERBB signaling pathway |
| negative regulation of extrinsic apoptotic signaling pathway |
| mitochondrial membrane |
| reactive oxygen species metabolic process |
| intrinsic apoptotic signaling pathway |
| regulation of extrinsic apoptotic signaling pathway |
| defense response to virus |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of apoptotic signaling pathway |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| response to virus |
| apoptotic signaling pathway |
| negative regulation of proteolysis |
| mitochondrial inner membrane |
| regulation of apoptotic signaling pathway |
| regulation of endopeptidase activity |
| regulation of membrane potential |
| mitochondrion organization |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| cytokine-mediated signaling pathway |
| regulation of proteolysis |
| innate immune response |
| ion homeostasis |
| negative regulation of catalytic activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| apoptotic process |
| defense response to other organism |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| immune effector process |
| cell death |
| response to cytokine |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| negative regulation of molecular function |
| mitochondrion |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of apoptotic process |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of cell death |
| intracellular signal transduction |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10581
- Expression level (log2 read counts): 3.12
Expression Distribution
IFI6 Expression in NALM6 Cells: 3.12
