IFITM5
Gene Information
- Official Symbol: IFITM5
- Official Name: interferon induced transmembrane protein 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 387733
- UniProt: A6NNB3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012].
- UniProt Summary: Required for normal bone mineralization. {ECO:0000269|PubMed:24519609}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9238
- Expression level (log2 read counts): -6.6
IFITM5 Expression in NALM6 Cells: -6.6
