IGFALS
Gene Information
- Official Symbol: IGFALS
- Official Name: insulin like growth factor binding protein acid labile subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 3483
- UniProt: P35858
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
- UniProt Summary: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3447
- Expression level (log2 read counts): -3.08
IGFALS Expression in NALM6 Cells: -3.08
