IL13
Gene Information
- Official Symbol: IL13
- Official Name: interleukin 13
- Aliases and Previous Symbols: N/A
- Entrez ID: 3596
- UniProt: P35225
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008].
- UniProt Summary: Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity). {ECO:0000250|UniProtKB:P20109, ECO:0000269|PubMed:8096327, ECO:0000269|PubMed:8097324}.
Pfam Domains GO Terms
Pfam Domains
| IL13 |
GO Terms
| positive regulation of pancreatic stellate cell proliferation |
| positive regulation of lung goblet cell differentiation |
| regulation of lung goblet cell differentiation |
| interleukin-13 receptor binding |
| negative regulation of lung ciliated cell differentiation |
| regulation of lung ciliated cell differentiation |
| positive regulation of connective tissue growth factor production |
| regulation of connective tissue growth factor production |
| regulation of pancreatic stellate cell proliferation |
| negative regulation of complement-dependent cytotoxicity |
| negative regulation of NAD(P)H oxidase activity |
| negative regulation of transforming growth factor beta production |
| regulation of NAD(P)H oxidase activity |
| regulation of complement-dependent cytotoxicity |
| positive regulation of mast cell activation involved in immune response |
| positive regulation of mast cell degranulation |
| positive regulation of mast cell activation |
| regulation of proton transport |
| negative regulation of cell killing |
| negative regulation of oxidoreductase activity |
| positive regulation of macrophage activation |
| positive regulation of leukocyte degranulation |
| negative regulation of endothelial cell apoptotic process |
| microglial cell activation |
| leukocyte activation involved in inflammatory response |
| positive regulation of myeloid leukocyte mediated immunity |
| regulation of mast cell degranulation |
| regulation of mast cell activation involved in immune response |
| regulation of transforming growth factor beta production |
| glial cell activation |
| positive regulation of release of sequestered calcium ion into cytosol |
| negative regulation of epithelial cell differentiation |
| positive regulation of B cell proliferation |
| neuroinflammatory response |
| negative regulation of epithelial cell apoptotic process |
| positive regulation of immunoglobulin production |
| regulation of mast cell activation |
| regulation of leukocyte degranulation |
| response to nicotine |
| positive regulation of fibroblast proliferation |
| macrophage activation |
| regulation of endothelial cell apoptotic process |
| regulation of macrophage activation |
| positive regulation of regulated secretory pathway |
| positive regulation of calcium ion transport into cytosol |
| regulation of myeloid leukocyte mediated immunity |
| positive regulation of epithelial cell differentiation |
| regulation of B cell proliferation |
| regulation of immunoglobulin production |
| positive regulation of tyrosine phosphorylation of STAT protein |
| positive regulation of calcium ion transmembrane transport |
| regulation of release of sequestered calcium ion into cytosol |
| cellular response to mechanical stimulus |
| regulation of tyrosine phosphorylation of STAT protein |
| regulation of epithelial cell apoptotic process |
| regulation of fibroblast proliferation |
| positive regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of smooth muscle cell proliferation |
| positive regulation of receptor signaling pathway via STAT |
| positive regulation of exocytosis |
| regulation of oxidoreductase activity |
| positive regulation of production of molecular mediator of immune response |
| positive regulation of cold-induced thermogenesis |
| regulation of calcium ion transport into cytosol |
| regulation of cell killing |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| response to ethanol |
| regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte mediated immunity |
| regulation of smooth muscle cell proliferation |
| regulation of receptor signaling pathway via STAT |
| positive regulation of leukocyte proliferation |
| regulation of production of molecular mediator of immune response |
| positive regulation of cation transmembrane transport |
| regulation of epithelial cell differentiation |
| regulation of cold-induced thermogenesis |
| regulation of calcium ion transmembrane transport |
| positive regulation of ion transmembrane transport |
| regulation of regulated secretory pathway |
| positive regulation of B cell activation |
| cytokine activity |
| positive regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of transmembrane transport |
| regulation of leukocyte mediated immunity |
| negative regulation of neuron death |
| positive regulation of intracellular transport |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| response to mechanical stimulus |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| regulation of exocytosis |
| response to alcohol |
| regulation of calcium ion transport |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of protein secretion |
| negative regulation of cytokine production |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| positive regulation of peptide secretion |
| response to antibiotic |
| regulation of neuron death |
| response to lipopolysaccharide |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| response to molecule of bacterial origin |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| cellular response to external stimulus |
| regulation of intracellular transport |
| positive regulation of lymphocyte activation |
| regulation of metal ion transport |
| external side of plasma membrane |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| positive regulation of protein transport |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| positive regulation of cytokine production |
| calcium ion homeostasis |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| regulation of immune effector process |
| regulation of ion transmembrane transport |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| inflammatory response |
| response to toxic substance |
| regulation of lymphocyte activation |
| regulation of vesicle-mediated transport |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| myeloid leukocyte activation |
| regulation of leukocyte activation |
| metal ion homeostasis |
| cellular cation homeostasis |
| regulation of cell activation |
| cellular ion homeostasis |
| cytokine-mediated signaling pathway |
| response to bacterium |
| regulation of cytokine production |
| regulation of ion transport |
| cation homeostasis |
| regulation of protein transport |
| negative regulation of cell differentiation |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| negative regulation of catalytic activity |
| regulation of secretion |
| response to lipid |
| positive regulation of immune response |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| leukocyte activation |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| positive regulation of transport |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| response to drug |
| regulation of protein localization |
| positive regulation of phosphorylation |
| cell activation |
| response to cytokine |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| extracellular region |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17003
- Expression level (log2 read counts): -4.01
Expression Distribution
IL13 Expression in NALM6 Cells: -4.01
