IL18BP
Gene Information
- Official Symbol: IL18BP
- Official Name: interleukin 18 binding protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 10068
- UniProt: O95998
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
- UniProt Summary: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. {ECO:0000269|PubMed:10023777, ECO:0000269|PubMed:10655506}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11831
- Expression level (log2 read counts): 4.55
IL18BP Expression in NALM6 Cells: 4.55
