IL27RA
Gene Information
- Official Symbol: IL27RA
- Official Name: interleukin 27 receptor subunit alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 9466
- UniProt: Q6UWB1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms. {ECO:0000269|PubMed:14764690}.
Pfam Domains GO Terms
Pfam Domains
| fn3 |
GO Terms
| negative regulation of T cell extravasation |
| interleukin-27 receptor activity |
| negative regulation of interleukin-17 secretion |
| regulation of interleukin-17 secretion |
| regulation of T cell extravasation |
| negative regulation of T cell migration |
| negative regulation of tumor necrosis factor secretion |
| negative regulation of cellular extravasation |
| negative regulation of T-helper 17 type immune response |
| interleukin-35-mediated signaling pathway |
| negative regulation of interleukin-6 secretion |
| interleukin-27-mediated signaling pathway |
| regulation of isotype switching to IgG isotypes |
| negative regulation of type 2 immune response |
| negative regulation of lymphocyte migration |
| negative regulation of interleukin-17 production |
| positive regulation of T-helper 1 type immune response |
| regulation of T-helper 17 type immune response |
| regulation of T-helper 1 type immune response |
| regulation of tumor necrosis factor secretion |
| regulation of cellular extravasation |
| regulation of interleukin-17 production |
| regulation of type 2 immune response |
| regulation of isotype switching |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| cytokine binding |
| negative regulation of interleukin-6 production |
| regulation of T cell migration |
| negative regulation of leukocyte migration |
| negative regulation of adaptive immune response |
| cytokine receptor activity |
| regulation of immunoglobulin mediated immune response |
| regulation of B cell mediated immunity |
| negative regulation of tumor necrosis factor production |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| regulation of lymphocyte migration |
| regulation of immunoglobulin production |
| positive regulation of interferon-gamma production |
| negative regulation of cytokine secretion |
| defense response to Gram-positive bacterium |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of DNA recombination |
| positive regulation of adaptive immune response |
| negative regulation of protein secretion |
| transmembrane signaling receptor activity |
| negative regulation of peptide secretion |
| regulation of interleukin-6 production |
| regulation of production of molecular mediator of immune response |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of immune response |
| regulation of tumor necrosis factor production |
| regulation of lymphocyte mediated immunity |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of adaptive immune response |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| regulation of leukocyte migration |
| negative regulation of secretion by cell |
| receptor complex |
| regulation of cytokine secretion |
| regulation of leukocyte mediated immunity |
| regulation of B cell activation |
| negative regulation of secretion |
| negative regulation of cell migration |
| negative regulation of cell motility |
| negative regulation of cytokine production |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| defense response to bacterium |
| regulation of DNA metabolic process |
| external side of plasma membrane |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of protein secretion |
| regulation of immune effector process |
| negative regulation of transport |
| regulation of peptide secretion |
| regulation of lymphocyte activation |
| regulation of leukocyte activation |
| regulation of cell activation |
| cytokine-mediated signaling pathway |
| response to bacterium |
| regulation of cytokine production |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| regulation of cell migration |
| positive regulation of immune response |
| regulation of cell motility |
| defense response to other organism |
| regulation of locomotion |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| response to cytokine |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| integral component of plasma membrane |
| negative regulation of response to stimulus |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| regulation of transport |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16075
- Expression level (log2 read counts): 3.5
Expression Distribution
IL27RA Expression in NALM6 Cells: 3.5
