IL7
Gene Information
- Official Symbol: IL7
- Official Name: interleukin 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 3574
- UniProt: P13232
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
Pfam Domains GO Terms
Pfam Domains
| IL7 |
GO Terms
| interleukin-7 receptor binding |
| positive regulation of B cell differentiation |
| interleukin-7-mediated signaling pathway |
| T cell lineage commitment |
| bone resorption |
| regulation of B cell differentiation |
| response to interleukin-7 |
| cellular response to interleukin-7 |
| homeostasis of number of cells within a tissue |
| negative regulation of signal transduction in absence of ligand |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| positive regulation of B cell proliferation |
| regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| bone remodeling |
| positive regulation of organ growth |
| positive regulation of cytokine-mediated signaling pathway |
| positive regulation of chemokine production |
| positive regulation of response to cytokine stimulus |
| regulation of B cell proliferation |
| regulation of chemokine production |
| positive regulation of T cell differentiation |
| regulation of organ growth |
| positive regulation of lymphocyte differentiation |
| tissue remodeling |
| negative regulation of extrinsic apoptotic signaling pathway |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| T cell differentiation |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| positive regulation of leukocyte differentiation |
| regulation of extrinsic apoptotic signaling pathway |
| regulation of cytokine-mediated signaling pathway |
| growth factor activity |
| positive regulation of B cell activation |
| regulation of lymphocyte differentiation |
| positive regulation of developmental growth |
| cytokine activity |
| regulation of response to cytokine stimulus |
| positive regulation of hemopoiesis |
| tissue homeostasis |
| homeostasis of number of cells |
| positive regulation of T cell activation |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of leukocyte proliferation |
| negative regulation of apoptotic signaling pathway |
| T cell activation |
| lymphocyte differentiation |
| cell fate commitment |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| positive regulation of growth |
| regulation of leukocyte differentiation |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| multicellular organismal homeostasis |
| regulation of developmental growth |
| leukocyte differentiation |
| anatomical structure homeostasis |
| humoral immune response |
| positive regulation of lymphocyte activation |
| collagen-containing extracellular matrix |
| lymphocyte activation |
| regulation of apoptotic signaling pathway |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of lymphocyte activation |
| hemopoiesis |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| regulation of cell activation |
| immune system development |
| regulation of growth |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| regulation of cytokine production |
| negative regulation of catalytic activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| leukocyte activation |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| cell activation |
| response to cytokine |
| cell-cell signaling |
| negative regulation of molecular function |
| positive regulation of immune system process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| immune response |
| extracellular region |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18071
- Expression level (log2 read counts): -1.82
Expression Distribution
IL7 Expression in NALM6 Cells: -1.82
