INCA1
Gene Information
- Official Symbol: INCA1
- Official Name: inhibitor of CDK, cyclin A1 interacting protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 388324
- UniProt: Q0VD86
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| cyclin-dependent protein serine/threonine kinase inhibitor activity |
| negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| cyclin binding |
| negative regulation of cyclin-dependent protein kinase activity |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| negative regulation of protein serine/threonine kinase activity |
| positive regulation of apoptotic signaling pathway |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| protein-containing complex binding |
| negative regulation of transferase activity |
| nuclear body |
| regulation of apoptotic signaling pathway |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| regulation of protein serine/threonine kinase activity |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| negative regulation of cell population proliferation |
| positive regulation of cell death |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| regulation of transferase activity |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| regulation of cell death |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3579
- Expression level (log2 read counts): 1.99
Expression Distribution
INCA1 Expression in NALM6 Cells: 1.99
