INPP5B
Gene Information
- Official Symbol: INPP5B
- Official Name: inositol polyphosphate-5-phosphatase B
- Aliases and Previous Symbols: N/A
- Entrez ID: 3633
- UniProt: P32019
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Exo endo phos |
| RhoGAP |
GO Terms
| inositol-1,4,5-trisphosphate 5-phosphatase activity |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |
| inositol phosphate dephosphorylation |
| phosphorylated carbohydrate dephosphorylation |
| inositol phosphate catabolic process |
| phosphatidylinositol dephosphorylation |
| polyol catabolic process |
| phospholipid dephosphorylation |
| alcohol catabolic process |
| inositol phosphate metabolic process |
| regulation of protein processing |
| regulation of protein maturation |
| flagellated sperm motility |
| sperm motility |
| phagocytic vesicle membrane |
| endoplasmic reticulum-Golgi intermediate compartment |
| organic hydroxy compound catabolic process |
| cilium-dependent cell motility |
| cilium or flagellum-dependent cell motility |
| polyol metabolic process |
| organophosphate catabolic process |
| early endosome membrane |
| phosphatidylinositol metabolic process |
| cellular carbohydrate metabolic process |
| lipid modification |
| glycerophospholipid metabolic process |
| dephosphorylation |
| alcohol metabolic process |
| regulation of small GTPase mediated signal transduction |
| phospholipid metabolic process |
| in utero embryonic development |
| glycerolipid metabolic process |
| small molecule catabolic process |
| organic hydroxy compound metabolic process |
| carbohydrate metabolic process |
| spermatogenesis |
| male gamete generation |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| gamete generation |
| regulation of proteolysis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| organophosphate metabolic process |
| cellular lipid metabolic process |
| embryo development |
| Golgi apparatus |
| multi-organism reproductive process |
| cell motility |
| localization of cell |
| lipid metabolic process |
| locomotion |
| reproductive process |
| reproduction |
| movement of cell or subcellular component |
| small molecule metabolic process |
| organic substance catabolic process |
| regulation of intracellular signal transduction |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Tenofovir 10μM R07 exp405 | -1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14988
- Expression level (log2 read counts): 6.05
Expression Distribution
INPP5B Expression in NALM6 Cells: 6.05
