IPO4
Gene Information
- Official Symbol: IPO4
- Official Name: importin 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 79711
- UniProt: Q8TEX9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000250, ECO:0000269|PubMed:11823430}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5756
- Expression level (log2 read counts): 6.65
IPO4 Expression in NALM6 Cells: 6.65
