IRS1
Gene Information
- Official Symbol: IRS1
- Official Name: insulin receptor substrate 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3667
- UniProt: P35568
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009].
- UniProt Summary: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250, ECO:0000269|PubMed:16878150}.
Pfam Domains GO Terms
Pfam Domains
| PH |
| IRS |
GO Terms
| insulin receptor complex |
| positive regulation of fatty acid beta-oxidation |
| insulin-like growth factor receptor signaling pathway |
| transmembrane receptor protein tyrosine kinase adaptor activity |
| positive regulation of fatty acid oxidation |
| insulin-like growth factor receptor binding |
| positive regulation of glycogen biosynthetic process |
| positive regulation of glycogen metabolic process |
| regulation of fatty acid beta-oxidation |
| interleukin-7-mediated signaling pathway |
| phosphatidylinositol 3-kinase binding |
| positive regulation of insulin receptor signaling pathway |
| insulin receptor binding |
| positive regulation of cellular response to insulin stimulus |
| positive regulation of lipid catabolic process |
| cellular response to interleukin-7 |
| regulation of glycogen biosynthetic process |
| regulation of glucan biosynthetic process |
| response to interleukin-7 |
| regulation of fatty acid oxidation |
| positive regulation of phosphatidylinositol 3-kinase activity |
| phosphatidylinositol 3-kinase signaling |
| negative regulation of insulin receptor signaling pathway |
| positive regulation of fatty acid metabolic process |
| regulation of glycogen metabolic process |
| SH2 domain binding |
| negative regulation of cellular response to insulin stimulus |
| positive regulation of lipid kinase activity |
| regulation of polysaccharide biosynthetic process |
| positive regulation of glucose import |
| positive regulation of glucose metabolic process |
| negative regulation of insulin secretion |
| phosphotyrosine residue binding |
| regulation of polysaccharide metabolic process |
| positive regulation of glucose transmembrane transport |
| negative regulation of peptide hormone secretion |
| positive regulation of phospholipid metabolic process |
| regulation of phosphatidylinositol 3-kinase activity |
| SH3/SH2 adaptor activity |
| protein kinase C binding |
| regulation of lipid catabolic process |
| regulation of glucose import |
| cellular response to fatty acid |
| positive regulation of cellular carbohydrate metabolic process |
| regulation of lipid kinase activity |
| negative regulation of hormone secretion |
| regulation of insulin receptor signaling pathway |
| phosphatidylinositol-mediated signaling |
| regulation of cellular response to insulin stimulus |
| regulation of glucose transmembrane transport |
| inositol lipid-mediated signaling |
| caveola |
| positive regulation of carbohydrate metabolic process |
| response to fatty acid |
| regulation of phospholipid metabolic process |
| regulation of fatty acid metabolic process |
| insulin receptor signaling pathway |
| regulation of carbohydrate biosynthetic process |
| regulation of glucose metabolic process |
| negative regulation of protein secretion |
| positive regulation of small molecule metabolic process |
| regulation of cellular carbohydrate metabolic process |
| negative regulation of peptide secretion |
| positive regulation of lipid metabolic process |
| regulation of generation of precursor metabolites and energy |
| cellular response to insulin stimulus |
| positive regulation of protein kinase B signaling |
| regulation of cellular ketone metabolic process |
| regulation of insulin secretion |
| negative regulation of protein transport |
| glucose homeostasis |
| negative regulation of establishment of protein localization |
| carbohydrate homeostasis |
| positive regulation of transmembrane transport |
| negative regulation of secretion by cell |
| regulation of carbohydrate metabolic process |
| cellular response to acid chemical |
| regulation of peptide hormone secretion |
| regulation of protein kinase B signaling |
| response to insulin |
| negative regulation of secretion |
| cellular response to peptide hormone stimulus |
| regulation of hormone secretion |
| cellular response to peptide |
| response to acid chemical |
| positive regulation of cellular catabolic process |
| MAPK cascade |
| response to peptide hormone |
| signal transduction by protein phosphorylation |
| regulation of lipid metabolic process |
| regulation of small molecule metabolic process |
| positive regulation of catabolic process |
| regulation of protein secretion |
| response to peptide |
| negative regulation of transport |
| regulation of peptide secretion |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cellular response to lipid |
| regulation of hormone levels |
| regulation of transmembrane transport |
| positive regulation of kinase activity |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| cytokine-mediated signaling pathway |
| intracellular membrane-bounded organelle |
| regulation of protein transport |
| enzyme linked receptor protein signaling pathway |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| regulation of cellular catabolic process |
| response to lipid |
| regulation of kinase activity |
| response to hormone |
| positive regulation of cell population proliferation |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of transport |
| regulation of catabolic process |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| response to cytokine |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| phosphorylation |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.408 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 5/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7430
- Expression level (log2 read counts): 5.77
Expression Distribution
IRS1 Expression in NALM6 Cells: 5.77
