JAG2
Gene Information
- Official Symbol: JAG2
- Official Name: jagged canonical Notch ligand 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 3714
- UniProt: Q9Y219
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| DSL |
| EGF |
| MNNL |
GO Terms
| epithelial cell apoptotic process involved in palatal shelf morphogenesis |
| gamma-delta T cell differentiation |
| inner ear receptor cell fate commitment |
| auditory receptor cell fate commitment |
| gamma-delta T cell activation |
| respiratory system process |
| epithelial cell fate commitment |
| apoptotic process involved in morphogenesis |
| thymic T cell selection |
| secondary palate development |
| inner ear auditory receptor cell differentiation |
| Notch binding |
| apoptotic process involved in development |
| epithelial cell apoptotic process |
| hair cell differentiation |
| T cell selection |
| respiratory gaseous exchange by respiratory system |
| negative regulation of Notch signaling pathway |
| neuroepithelial cell differentiation |
| T cell differentiation in thymus |
| inner ear receptor cell differentiation |
| positive regulation of Notch signaling pathway |
| mechanoreceptor differentiation |
| neuron fate commitment |
| odontogenesis of dentin-containing tooth |
| roof of mouth development |
| columnar/cuboidal epithelial cell differentiation |
| regulation of Notch signaling pathway |
| odontogenesis |
| Notch signaling pathway |
| T cell differentiation |
| morphogenesis of embryonic epithelium |
| growth factor activity |
| inner ear development |
| ear development |
| T cell activation |
| lymphocyte differentiation |
| cell fate commitment |
| epidermal cell differentiation |
| leukocyte differentiation |
| in utero embryonic development |
| lymphocyte activation |
| epidermis development |
| morphogenesis of an epithelium |
| skeletal system development |
| spermatogenesis |
| sensory organ development |
| hemopoiesis |
| male gamete generation |
| tissue morphogenesis |
| embryonic morphogenesis |
| hematopoietic or lymphoid organ development |
| chordate embryonic development |
| immune system development |
| embryo development ending in birth or egg hatching |
| regulation of cell adhesion |
| epithelial cell differentiation |
| gamete generation |
| calcium ion binding |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| apoptotic process |
| leukocyte activation |
| animal organ morphogenesis |
| embryo development |
| multi-organism reproductive process |
| neuron differentiation |
| programmed cell death |
| cell activation |
| cell death |
| epithelium development |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| generation of neurons |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of signal transduction |
| tissue development |
| positive regulation of cell communication |
| positive regulation of signaling |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Oligomycin-A 20μM R00 exp26 | -1.9 |
| CI-1040 9.5μM R08 exp472 | 1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4415
- Expression level (log2 read counts): -0.05
Expression Distribution
JAG2 Expression in NALM6 Cells: -0.05
