KAT5
Gene Information
- Official Symbol: KAT5
- Official Name: lysine acetyltransferase 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 10524
- UniProt: Q92993
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| MOZ SAS |
| Tudor-knot |
GO Terms
| Piccolo NuA4 histone acetyltransferase complex |
| peptide-lysine-N-acetyltransferase activity |
| H4 histone acetyltransferase activity |
| Swr1 complex |
| DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
| DNA damage response, signal transduction resulting in transcription |
| acetyltransferase activity |
| NuA4 histone acetyltransferase complex |
| DNA double-strand break processing |
| negative regulation of interleukin-2 production |
| histone acetyltransferase complex |
| beta-catenin-TCF complex assembly |
| androgen receptor signaling pathway |
| cellular response to estradiol stimulus |
| repressing transcription factor binding |
| positive regulation of protein acetylation |
| androgen receptor binding |
| histone acetyltransferase activity |
| regulation of interleukin-2 production |
| histone H4 acetylation |
| double-strand break repair via nonhomologous end joining |
| non-recombinational repair |
| intracellular steroid hormone receptor signaling pathway |
| regulation of protein acetylation |
| DNA damage response, signal transduction by p53 class mediator |
| signal transduction in response to DNA damage |
| histone acetylation |
| internal peptidyl-lysine acetylation |
| steroid hormone mediated signaling pathway |
| positive regulation of autophagy |
| signal transduction by p53 class mediator |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| histone binding |
| response to estradiol |
| protein acetylation |
| response to ionizing radiation |
| intracellular receptor signaling pathway |
| hormone-mediated signaling pathway |
| regulation of signal transduction by p53 class mediator |
| double-strand break repair |
| cellular response to steroid hormone stimulus |
| protein acylation |
| transcription factor complex |
| DNA replication |
| nuclear chromatin |
| negative regulation of cytokine production |
| transcription coactivator activity |
| peptidyl-lysine modification |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| response to steroid hormone |
| regulation of autophagy |
| proteasomal protein catabolic process |
| positive regulation of cellular catabolic process |
| histone modification |
| covalent chromatin modification |
| positive regulation of catabolic process |
| response to radiation |
| DNA repair |
| cellular response to lipid |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| cellular response to organic cyclic compound |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular response to hormone stimulus |
| cellular protein catabolic process |
| regulation of growth |
| protein catabolic process |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| chromatin organization |
| viral process |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| symbiotic process |
| interspecies interaction between organisms |
| regulation of cellular catabolic process |
| response to lipid |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| peptidyl-amino acid modification |
| cellular macromolecule catabolic process |
| response to hormone |
| response to organic cyclic compound |
| regulation of catabolic process |
| macromolecule catabolic process |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| chromosome organization |
| response to abiotic stimulus |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| proteolysis |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PRR12 | 0.404 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 78/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 4/28 |
| bone | 2/25 |
| breast | 4/33 |
| central nervous system | 5/56 |
| cervix | 0/4 |
| colorectal | 2/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 4/21 |
| liver | 2/20 |
| lung | 8/75 |
| lymphocyte | 3/14 |
| ovary | 2/26 |
| pancreas | 1/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 5/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 3/22 |
| urinary tract | 4/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 271
- Expression level (log2 read counts): 5.58
Expression Distribution
KAT5 Expression in NALM6 Cells: 5.58
