UniProt Summary: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
ER lumen recept
GO Terms
KDEL sequence binding
COPI-coated vesicle membrane
protein retention in ER lumen
maintenance of protein localization in endoplasmic reticulum
maintenance of protein localization in organelle
IRE1-mediated unfolded protein response
cis-Golgi network
maintenance of protein location in cell
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
transport vesicle
maintenance of location in cell
endoplasmic reticulum unfolded protein response
maintenance of protein location
cellular response to unfolded protein
protein localization to endoplasmic reticulum
cellular response to topologically incorrect protein
response to unfolded protein
maintenance of location
response to topologically incorrect protein
endoplasmic reticulum to Golgi vesicle-mediated transport
response to endoplasmic reticulum stress
Golgi vesicle transport
Golgi membrane
protein localization to organelle
endoplasmic reticulum membrane
Golgi apparatus
endoplasmic reticulum
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
cellular response to stress
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)