KLHL6
Gene Information
- Official Symbol: KLHL6
- Official Name: kelch like family member 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 89857
- UniProt: Q8WZ60
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
- UniProt Summary: Involved in B-lymphocyte antigen receptor signaling and germinal center formation. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12675
- Expression level (log2 read counts): 6.42
KLHL6 Expression in NALM6 Cells: 6.42
