KLHL7
Gene Information
- Official Symbol: KLHL7
- Official Name: kelch like family member 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 55975
- UniProt: Q8IXQ5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010].
- UniProt Summary: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. {ECO:0000269|PubMed:21828050}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8161
- Expression level (log2 read counts): 5.46
KLHL7 Expression in NALM6 Cells: 5.46
