KRT14
Gene Information
- Official Symbol: KRT14
- Official Name: keratin 14
- Aliases and Previous Symbols: N/A
- Entrez ID: 3861
- UniProt: P02533
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008].
- UniProt Summary: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. {ECO:0000269|PubMed:11724817}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2971
- Expression level (log2 read counts): -2.11
KRT14 Expression in NALM6 Cells: -2.11
