Entrez Summary: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009].
UniProt Summary: Probably contributes to terminal cornification. {ECO:0000269|PubMed:1282112}.
Pfam DomainsGO Terms
Pfam Domains
Filament
GO Terms
sebaceous gland development
pigmentation
keratin filament
cornification
intermediate filament
keratinization
keratinocyte differentiation
epidermal cell differentiation
skin development
gland development
epidermis development
epithelial cell differentiation
programmed cell death
cell death
cytoskeleton organization
epithelium development
tissue development
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739