Entrez Summary: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
Filament
GO Terms
keratin filament
cornification
keratinization
keratinocyte differentiation
epidermal cell differentiation
cytoskeleton
skin development
epidermis development
epithelial cell differentiation
molecular function
programmed cell death
cell death
epithelium development
tissue development
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)