Entrez Summary: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
Filament
GO Terms
nail development
structural constituent of epidermis
regulation of keratinocyte differentiation
regulation of epidermal cell differentiation
hair follicle development
skin epidermis development
molting cycle process
hair cycle process
regulation of epidermis development
hair cycle
molting cycle
keratin filament
structural constituent of cytoskeleton
cornification
regulation of epithelial cell differentiation
appendage development
limb development
keratinization
keratinocyte differentiation
epidermal cell differentiation
skin development
epidermis development
epithelial cell differentiation
programmed cell death
cell death
cytoskeleton organization
epithelium development
tissue development
regulation of cell differentiation
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)