Entrez Summary: This gene encodes a type II keratin protein, which heterodimerizes with type I keratins to form hair and nails. This gene is present in a cluster of related genes and pseudogenes on chromosome 12. Mutations in this gene have been observed in patients with the hair disease monilethrix. [provided by RefSeq, Feb 2016].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
Filament
GO Terms
keratin filament
cornification
keratinization
keratinocyte differentiation
epidermal cell differentiation
skin development
epidermis development
epithelial cell differentiation
programmed cell death
cell death
epithelium development
extracellular space
tissue development
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739